Ageing and Esthetics
Immunosenescence - counter mechanisms
Ageing is accompanied by decreased immunity and increased inflammatory responses (‘inflammaging’) inducing a chronic low-grade inflammatory profile (CLIP). Exercise increases both physical fitness and immunity, which can be beneficial for the elderly. However, resistance exercise (RE) is not often implemented as therapeutic strategy in the clinics.
The exercise-induced anti-inflammatory response is linked to exercise intensity and duration. Therefore, correct exercise training is essential to obtain proper effects. In the proposed project, we will compare different RE programs to investigate the effects of different training programs on inflammation in healthy older adults. Markers and genes involved in inflammation will be measured in peripheral blood and skin biopsies. We anticipate that the outcomes provide us an overview of important anti-inflammatory genes and that we can make a link between circulating and skin inflammatory markers. The proposed project is a step forward towards future application of RE in geriatric patients as additive therapy to accelerate their recovery and pathologies related to inflammation. In addition, if the use of skin biopsies shows to be an effective model for measurement of the anti-inflammatory response in the mucles, this will improve future studies as this is less invasive. The present project is based on a collaboration between the Department of Gerontology and Dermatology at the VUB.
Lasers for treatment of scars
Scars can develop after dermal injury, such as surgery, trauma and skin inflammation. Formation of scar tissue is characterized by inflammatory cells and increased proliferation of fibroblasts. Treatment of scars with lasers is still a relatively new treatment approach. Laser therapy decreases vasculatrization leading to tissue hypoxia which results in increased cell catabolism and reduced collagen production.
The combination of different lasers may improve the efficacy and lower the risk profile. In the present study, we aim to investigate the effect of combined laser therapy on the aesthetic outcomes. This study will be performed in collaboration with Uniklinikum in Aachen, Germany.